Francisella tularensis subsp. novicida U112

• Map 1
• T6SS gene clusters 1
• Effectors 10
• Immunity proteins 0
• Recipient susceptibility factors 0
• Regulators 6
• Accessory proteins 1

• NC_008601 (chromosome)

NC_008601 (chromosome)
 

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Experimental investigation has been performed.
Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function
T6SS00158	ii	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1378294..1404786	anti-eukaryotic; effector translocation; virulence

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0173	FTN_RS06610 (mglA)	T6SS00158	protein	TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1362282..1362899 (+)	489124662	iglC transcription (↓); Unknown (↓)
REG0174	FTN_RS02845 (SspA)	T6SS00158	protein	TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	574840..575472 (+)	500053699	FTN_1465 (pmrA) (↓)
REG0175	FTN_RS08805 (KdpD)	T6SS00158	protein	TCS-HK	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1838601..1841282 (-)	489131611	FTN_1465 (pmrA) (↓)
REG0176	FTN_1465 (pmrA)	T6SS00158	protein	TCS-RR; TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1553358..1554044 (-)	489108239	FTN_1465 (pmrA) promotor (↓); pdpD promotor (↓); IglA expression (↓)
REG0177	FTN_RS06615 (mglB)	T6SS00158	protein	Global regulator; TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1362901..1363308 (+)	489112095	IglA expression (↓); T6SS Transciption (↓)
REG0178	FTN_0480 (fevR/PigR)	T6SS00158	protein	TCS regulatory pathway	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	486541..486876 (+)	489108070	T6SS Transciption (↓)

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID
EFF01494	FTN_1319 (pdpC)	Tle	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1391204..1395181 (+)	118497899
EFF01487	FTN_0131 (opiA)	Tse	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	143587..144894 (-)	118496746
EFF01489	FTN_1325 (pdpD)	Tse	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1399803..1403540 (-)	118497905
EFF01491	FTN_1069 (OpiB-1)	Tse	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1128155..1130653 (-)	118497660
EFF01492	FTN_1070 (OpiB-2)	Tse	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1130861..1132213 (-)	118497661
EFF01493	FTN_1071 (OpiB-3)	Tse	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1132421..1133899 (-)	118497662
EFF00204	FTN_1317 (IglI)	-	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1389274..1390425 (+)	118497897
EFF00203	FTN_1312 (VgrG)	-	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1384422..1384916 (+)	118497892
EFF01488	FTN_1309 (pdpA)	-	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1378294..1380756 (+)	118497889
EFF01490	FTN_1322 (iglC)	-	-	T6SS00158	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1396989..1397618 (-)	118497902

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector

Experimental investigation has been performed.
Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector
ACP00023	FTN_RS06580 (dnaK)	T6SS00158	chaperone	Francisella tularensis subsp. novicida U112	chromosome (NC_008601)	1356202..1358130 (-)	489130276	FTN_RS08950 (ClpB)	-